Completed fertility effects of family policy measures : evidence from a life-cycle model

We estimate a structural life-cycle model of fertility and female labour supply and use it to evaluate the effects of a number of key family policy measures based on data for Germany. Parental leave benefits, child benefits and subsidized childcare are found to have substantial fertility effects. Without these measures, completed fertility is estimated to be lower by 6%, 7%, and 10%, respectively. Income tax splitting, which is fiscally expensive, reduces female labour supply but has a negligible effect on fertility

Advancing purchasing as a design science: Publication guidelines to shift towards more relevant purchasing research

Stange, R., Schiele, H., & Henseler, J. (2022). Advancing purchasing as a design science: Publication guidelines to shift towards more relevant purchasing research. Journal of Purchasing and Supply Management, 28(1), 1-12. [100750]. https://doi.org/10.1016/j.pursup.2022.100750Due to rapidly changing business environments, purchasing and supply management (PSM) organisations are constantly confronted with new problems impacting organisational performance. PSM research can address these problems through design science research. Design science is also regarded as the science of the artificial. Design science research is a methodology that aims to systematically generate knowledge for the design, synthesis, testing, and evaluation of human-made artefacts (e.g., tools, interventions, policies) that solve practical problems. PSM artefacts such as the purchasing portfolio matrix invented by Kraljic (1983) represent a valuable opportunity to solve problems in the PSM discipline. However, our artificial-intelligence (AI)-based analysis of the discipline's flagship journal, the Journal of Purchasing and Supply Management (JPSM), indicates that design-oriented publications in PSM are underrepresented, accounting for less than 4% of the total publications. We argue that existing PSM research should be complemented with more design-oriented research, and address the following research question: How can PSM scholars publish more design-oriented research? Our objectives are to (1) provide arguments for advancing PSM as a design science, (2) nurture a better understanding of design science research as a methodology, and (3) propose publication guidelines that enable researchers to present design-oriented research in a management journal.publishersversionpublishe

Ca2+ tunnelling through the ER lumen as a mechanism for delivering Ca2+ entering via store-operated Ca2+ channels to specific target sites

Ca2+ signaling is perhaps the most universal and versatile mechanism regulating a wide range of cellular processes. Because of the many different calcium-binding proteins distributed throughout cells, signaling precision requires localized rises in the cytosolic Ca2+ concentration. In electrically non-excitable cells, for example epithelial cells, this is achieved by primary release of Ca2+ from the endoplasmic reticulum via Ca2+ release channels placed close to the physiological target. Because any rise in the cytosolic Ca2+ concentration activates Ca2+ extrusion, and in order for cells not to run out of Ca2+, there is a need for compensatory Ca2+ uptake from the extracellular fluid. This Ca2+ uptake occurs through a process known as store-operated Ca2+ entry. Ideally Ca2+ entering the cell should not diffuse to the target site through the cytosol, as this would potentially activate undesirable processes. Ca2+ tunneling through the lumen of the endoplasmic reticulum is a mechanism for delivering Ca2+ entering via store-operated Ca2+ channels to specific target sites, and this process has been described in considerable detail in pancreatic acinar cells and oocytes. Here we review the most important evidence and present a generalized concept

Validation of a Sapphire Gas-Pressure Cell for Real-Time In Situ Neutron Diffraction Studies of Hydrogenation Reactions

A gas-pressure cell, based on a leuco-sapphire single-crystal, serving as a pressure vessel and sample holder, is presented for real time in situ studies of solid-gas hydrogenation reactions. A stainless steel corpus, coated with neutron absorbing varnish, allows alignment for the single-crystal sample holder for minimizing contributions to the diffraction pattern. Openings in the corpus enable neutron scattering as well as contactless temperature surveillance and laser heating. The gas-pressure cell is validated via the deuteration of palladium powder, giving reliable neutron diffraction data at the high-intensity diffractometer D20 at the Institut Laue-Langevin (ILL), Grenoble, France. It was tested up to 15.0 MPa of hydrogen pressure at room temperature, 718 K at ambient pressure and 584 K at 9.5 MPa of hydrogen pressure

Augmented Air Traffic Control System—Artificial Intelligence as Digital Assistance System to Predict Air Traffic Conflicts

Today’s air traffic management (ATM) system evolves around the air traffic controllers and pilots. This human-centered design made air traffic remarkably safe in the past. However, with the increase in flights and the variety of aircraft using European airspace, it is reaching its limits. It poses significant problems such as congestion, deterioration of flight safety, greater costs, more delays, and higher emissions. Transforming the ATM into the “next generation” requires complex human-integrated systems that provide better abstraction of airspace and create situational awareness, as described in the literature for this problem. This paper makes the following contributions: (a) It outlines the complexity of the problem. (b) It introduces a digital assistance system to detect conflicts in air traffic by systematically analyzing aircraft surveillance data to provide air traffic controllers with better situational awareness. For this purpose, long short-term memory (LSTMs) networks, which are a popular version of recurrent neural networks (RNNs) are used to determine whether their temporal dynamic behavior is capable of reliably monitoring air traffic and classifying error patterns. (c) Large-scale, realistic air traffic models with several thousand flights containing air traffic conflicts are used to create a parameterized airspace abstraction to train several variations of LSTM networks. The applied networks are based on a 20–10–1 architecture while using leaky ReLU and sigmoid activation function. For the learning process, the binary cross-entropy loss function and the adaptive moment estimation (ADAM) optimizer are applied with different learning rates and batch sizes over ten epochs. (d) Numerical results and achievements by using LSTM networks to predict various weather events, cyberattacks, emergency situations and human factors are presented

STATE-OF-THE-ART PROZESSORIENTIERTER KRANKENHAUSINFORMATIONSSYSTEME

Die Informationstechnologie gewinnt im Krankenhaus zunehmend strategische Bedeutung. Die dem Beitrag zugrunde liegende Studie analysiert die wesentlichen Erfolgsfaktoren eines zukunftsorientierten Krankenhausinformationssystems für Deutschland. Im Hinblick auf das eingeführte diagnosebezogene Fallpauschalensystem sind das im Rahmen der Prozessorientierung die Unterstützung der Einführung und Nutzung von klinischen Pfaden insbesondere durch Workflow Management Systeme sowie die automatisierte Verwendung von Expertenwissen im Rahmen von Experten- und Wissensbasierten Systemen. Im Zuge der knapper werdenden Ressourcen beim medizinischen Personal (Ärzte und Pflege) in Krankenhäusern werden die Analysekriterien ausgewählt und erläutert und in der Folge auf die am Markt befindlichen Krankenhausinformationssysteme angewandt. Abschließend werden die Ergebnisse zusammenfassend bewertet

Comparison of calling pipelines for whole genome sequencing: an empirical study demonstrating the importance of mapping and alignment

Rapid advances in high-throughput DNA sequencing technologies have enabled the conduct of whole genome sequencing (WGS) studies, and several bioinformatics pipelines have become available. The aim of this study was the comparison of 6 WGS data pre-processing pipelines, involving two mapping and alignment approaches (GATK utilizing BWA-MEM2 2.2.1, and DRAGEN 3.8.4) and three variant calling pipelines (GATK 4.2.4.1, DRAGEN 3.8.4 and DeepVariant 1.1.0). We sequenced one genome in a bottle (GIAB) sample 70 times in different runs, and one GIAB trio in triplicate. The truth set of the GIABs was used for comparison, and performance was assessed by computation time, F1 score, precision, and recall. In the mapping and alignment step, the DRAGEN pipeline was faster than the GATK with BWA-MEM2 pipeline. DRAGEN showed systematically higher F1 score, precision, and recall values than GATK for single nucleotide variations (SNVs) and Indels in simple-to-map, complex-to-map, coding and non-coding regions. In the variant calling step, DRAGEN was fastest. In terms of accuracy, DRAGEN and DeepVariant performed similarly and both superior to GATK, with slight advantages for DRAGEN for Indels and for DeepVariant for SNVs. The DRAGEN pipeline showed the lowest Mendelian inheritance error fraction for the GIAB trios. Mapping and alignment played a key role in variant calling of WGS, with the DRAGEN outperforming GATK

Intravitreal treatment in patients with exudative age-related macular degeneration and visual acuity ≤ 0.05

Background: To investigate intravitreal treatment efficiencies in patients suffering from exudative ARMD with a BCVA ≤ 0.05. Methods: Retrospective analysis: Analysis parameters were lesion type, BCVA at baseline and at follow-up, the intravitreal drug used, and its application frequency. Patients were divided into: 1) following injections of bevacizumab, triamcinolone, their combination, or ranibizumab regardless of their lesion subtype, 2) or by lesion subtype. Statistical tests were performed using Wilcoxon signed-rank tests, Kruskal-Wallis tests and multivariable logistic regressions. Results: Seventy four eyes of 74 patients were analyzed. Follow-up was at 12.0 to 15.7 weeks. Median difference of BCVA (logMAR) between baseline and follow-up was 0.000 (−0.030, 0.175) in classic (p = 0.105), 0.000 (−1.15, 0.20) in occult (p = 0.005), −0.200 (−1.20, 0.60) in cases with subretinal fluid (p = 0.207), 0.000 (-0.60, 0.30) in pigment epithelial detachment (p = 0.813), and 0.050 (−0.40, 0.70) in Junius Kuhnt maculopathy (p = 0.344). BCVA increased ≥ 0.2 logMAR in 4 (24 %) classic, 9 (47 %) occult, 6 (33 %) pigment epithelial detachment, 6 (55 %) subretinal fluid, in 29 (39 %) eyes regardless of the lesion type, and reached a BCVA ≥ 0.05 in 7 (9 %) of those with a baseline BCVA <0.05. Conclusions: Results indicate that in patients with ARMD and a BCVA lower 0.05, intravitreal treatment may improve visual acuity, most probably in cases with occult lesions.<br

Form-flexible handling and joining technology (formhand) for the forming and assembly of limp materials

The assembly of limp, elastic or differently shaped objects poses a huge challenge which needs to be met by machine tools and the corresponding processes of handling, forming and joining. These processes are often carried out manually. This technological gap triggered the present work at the Technische Universität Braunschweig. A novel form-flexible handling tool (FormHand) is presented which focuses on the automation of these production steps taking into consideration the material behavior. The combination of the flexibility of both industrial robot and the FormHand end-effector allows for new processes appropriate for these materials. This article investigates the used materials of the granular filler and the cushion textile, the working states of FormHand and the use of online sensors for an automated process application